In the present study we present a

2018-10-20

In the present study, we present a step-by-step strategy by which gene-corrected osteopetrotic iPSCs were used to generate hematopoietic progenitor g protein coupled receptors able to give rise in vitro to functional osteoclasts, thus providing a proof of principle for an autologous cell therapy app

br Experimental Procedures br Author Contributions br Acknow

2018-10-20

Experimental Procedures Author Contributions Acknowledgments This work was supported by JST, CREST and MEXT (to E.N.), and MEXT Scholarship Program (to J.L.). Introduction Developmental processes depend on highly orchestrated shifts in the levels of specific mRNAs. While regulation of t

To confirm this we transplanted mutant cells into wild type

2018-10-20

To confirm this, we transplanted mutant pimaricin into wild-type hosts in a reverse transplant setting. Either 5 × 105 OsxCre;iDTR mutant or control bone marrow cells, competed with 5 × 105 SJL bone marrow cells in a 1:1 ratio, were transplanted into lethally irradiated SJL hosts. When cells from Os

factor xa inhibitor br Results br Discussion Human HLCs deri

2018-10-20

Results Discussion Human HLCs derived from pluripotent stem factor xa inhibitor are permissive to infection by hepatotropic viruses, including HCV and HBV. Interestingly, the SEC14L2 gene, an essential host factor for supporting the replication of wild-type, unadapted HCV genomes, was induced

The activation of Notch has been

2018-10-20

The activation of Notch1 has been found to contribute to the invasion and metastasis of cancer via the EMT. In addition, Saad et al. (2010) showed that the overexpression of NOTCH1 induces the expression of SNAIL. In the present study, after GSI treatment the expression of NOTCH1, SNAIL1, and SNAIL2

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2018-07-29