• The functional roles of SOX in human pluripotency maintenanc

  2018-10-22

  

  The functional roles of SOX2 in human pluripotency maintenance and lineage differentiation were recently reported (Wang et al., 2012). SOX2 is not essential for hESC self-renewal. However, overexpression of SOX2 results in the promotion of neural ectodermal differentiation and the suppression of def

• Several cytokines and chemokines possess important chemo att

  2018-10-20

  

  Several cytokines and chemokines possess important chemo-attractant functions during fetal CNS development (Stumm and Hollt, 2007; Li and Ransohoff, 2008). This suggests that neural stem and precursor buy LY2109761 may respond to cues by these mediators of inflammation in immune-mediated pathologic

• Previously we demonstrated that injured kidney tissues can

  2018-10-20

  

  Previously, we demonstrated that injured kidney tissues can induce bone marrow stromal p-Cresyl sulfate to differentiate into renal tubular epithelial-like cells in vitro and in vivo (Qian et al., 2008). However, another work reported that the beneficial effects of BMSCs are primarily mediated by c

• Finally the potential contribution of CD b cells to

  2018-10-20

  

  Finally, the potential contribution of CD11b+ salt inducible kinase to the regenerative microenvironment highlights the experimental challenges in defining the mechanism of lung growth. The distinct transcriptional profiles of the CD11b+ cells, and their migration into different anatomic compartmen

• Intestinal stem cells have been identified by various marker

  2018-10-20

  

  Intestinal stem cells have been identified by various markers, such as musashi-1 (Msi1), hairy enhancer of split-1 (Hes1), CD133, leucine-rich repeats and immunoglobulin-like domains protein 1 (Lrig1) (Kayahara et al., 2003; Potten et al., 2003; O\'Brien et al., 2007; Wong et al., 2012). More recent

• The following are the supplementary data related

  2018-10-20

  

  The following are the supplementary data related to this article. Acknowledgments Introduction Inflammation, trauma and tumors may all lead to articular cartilage defects. However, the treatment of these defects remains a clinical challenge. Currently, clinical treatments for articular cartil

• ppar gamma agonist A recent study showed that mesenchymal AL

  2018-10-20

  

  A recent study showed that mesenchymal ALK5 regulates the balance between smooth muscle versus lipofibroblast differentiation and that ALK5 inhibition shifts the balance towards lipofibroblast (Li et al., 2014). Thus, it is possible that the enhancing effect of ALK5-I we observed in our culture syst

• br Resource details Human skin fibroblasts

  2018-10-20

  

  Resource details Human skin fibroblasts isolated from a 26year old Puerto Rican female HPS1 patient were obtained from the Coriell Cell Repositories (Camden, NJ). The parental line, GM14609, carries a homozygous 16bp duplication (codons 491–496) in exon 15 of the HPS1 gene. The latrunculin were

• The following is the supplementary data related to

  2018-10-20

  

  The following is the supplementary data related to this article. Authors\' contributions O.F. contributed to prepare experimental design, performed Ca measurements, helped with data and statistical analysis, immunocytochemistry, confocal imaging, and contributed in manuscript writing. Disclos

• br The ethics of cell therapy Clearly then cell

  2018-10-20

  

  The ethics of cell therapy Clearly then, cell therapy and regenerative medicine in general raise a number of ethical, economical and regulatory issues that were addressed in an ad hoc session. As a general introduction to this very complex landscape, John Harris (University of Manchester) took le

• The negative long term effects of

  2018-10-20

  

  The negative, long term effects of alcoholism on bone mass have been well-established (Feskanich et al., 1999). Studies have shown that heavy chronic alcohol consumption compromises bone quality and increases the risk for osteoporosis. Other studies have shown that alcoholism is associated with a va

• Induction of EndMT results from integration of

  2018-10-20

  

  Induction of EndMT results from integration of multiple extrinsic inputs within the dynamically shifting cellular environment of cardiogenesis. Owing to the membrane bound presentation of ligands, Notch signaling status is dependent on the organization and distribution of signal-presenting and signa

• The bromodomain and extraterminal BET family of bromodomain

  2018-10-20

  

  The bromodomain and extraterminal (BET) family of bromodomain-containing proteins (Brds), including Brd2, Brd3, Brd4, and testis-specific BrdT, are epigenetic readers of the acetylation histone code on chromatin. The two tandem bromodomains of BET proteins bind acetylated lysine in histone N-termina

• br Materials and methods br Acknowledgements This study

  2018-10-20

  

  Materials and methods Acknowledgements This study was supported by the European Union within the 7th European Community Framework Programme through funding for the NEUROMICS network (F5-2012-305121 to L.S.), the Marie Curie International Outgoing Fellowship (grant PIOF-GA-2012-326681 to R.S. a

• The numbers of GFAP NSCs did not

  2018-10-20

  

  The numbers of GFAP+ NSCs did not return to control levels at even the longest survival times examined (approximately 1 month after AraC and GCV treatment). One possible explanation for this is that we simply did not wait long enough to observe the complete return to control values. Alternatively, t

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