• Cancer stem cells CSCs may

  2024-04-11

  

  Cancer stem cells (CSCs) may have been first identified in teratocarcinomas [11], [12], with its initial clues date back to the 19th century [13]. Kleinsmith and Pierce [12] established the immortal pluripotent teratocarcinoma lines from a single transplanted multi-potent malignant cell, strongly su

• The second evidence comes from the

  2024-04-10

  

  The second evidence comes from the results obtained by patch-clamp recordings carried out at the endplate region of isolated mouse FDB fibers, where adenosine and the P1R agonist NECA significantly affected the NPo, the open frequency and the time constant τ of the adult nAChR channels. It is genera

• Small RhoGTPases are single domain nucleotide dependent

  2024-04-10

  

  Small RhoGTPases are single-domain nucleotide-dependent binary switches that act as highly-tuned regulators in signal transduction [1]. The cycling between active GTP-bound and inactive GDP-bound forms allows RhoGTPases to bind to or to dissociate from downstream effectors, respectively [2]. Guanine

• Rucaparib free base br Results br Discussion The actin

  2024-04-10

  

  Results Discussion The Rucaparib free base cytoskeleton is a highly attractive target for many bacterial toxins, owing to its role in activation and locomotion of immune cells, secretion of humoral response factors, and maintenance of protective barriers at the cellular (sub-membrane cytoskele

• The first rationally designed dual mPGES LO inhibitor was re

  2024-04-10

  

  The first rationally designed dual mPGES-1/5-LO inhibitor was reported in 2008 and represents a structural derivative of pirinixic na+/ca2+ exchanger - a synthetic agonist of PPARα with lipid-lowering properties (Koeberle et al., 2008b). Further α-alkyl- and α-aryl-substituted derivatives have been

• Introduction Chronic inflammation is increasingly known

  2024-04-10

  

  Introduction Chronic inflammation is increasingly known as one of the most critical etiological factors in gastrointestinal (GI) cancers (Lee et al., 2016; Wang and Cho, 2015). Overexpression of 5-lipoxygenase (5-LOX), 5-LOX-activating protein (FLAP), as well as other leukotriene (LT) biosynthetic

• Over the past decade extensive

  2024-04-10

  

  Over the past decade, extensive research has been directed toward the discovery of Aurora-selective small-molecule inhibitors. As a result, a handful of Aurora inhibitors has been identified. Among them, 1 (VX-680) and 2 (SNS-314) have entered human clinical trials as pan-Aurora kinase inhibitors (F

• br Conclusions In the current study we found that

  2024-04-10

  

  Conclusions In the current study, we found that the exposure of maduramicin to chicken myocardial SB-3CT sale results in cellular damage and even death via the induction of apoptosis. Maduramicin upregulated the expression of apoptotic genes and activated caspase cascades, which were accompanied

• In the early s in addition to above mentioned plant

  2024-04-10

  

  In the early 2000s, in addition to above-mentioned plant derived compounds, several peptide fragments from protein sources (e.g. gelatin, egg yolk, meat, fish, chicken, legumes) have been also confirmed as potential natural antioxidants and extensive studies about bioactive peptides have been conduc

• br Results and discussion The soil fungus PSU RSPG BCC

  2024-04-10

  

  Results and discussion The soil fungus PSU-RSPG37 (BCC56870) was isolated from soil samples collected from Rajjaprabha Dam, Suratthani Province, Thailand. The fungus was deposited at BIOTEC Culture Collection, National Center for Genetic Engineering and Biotechnology (BIOTEC), Thailand Science Pa

• GSK 2837808A br Conclusion br Competing interests br Funding

  2024-04-10

  

  Conclusion Competing interests Funding The Bolger Prostate Cancer Research Fund (no grant number), the National Institute of General Medical Sciences of the National Institutes of Health (1-R01-GM58553, G. B. Bolger, principal investigator), and the National Cancer Institute of the NIH to t

• Another hypothesis is angiogenesis inhibition Angiogenesis i

  2024-04-10

  

  Another hypothesis is angiogenesis inhibition. Angiogenesis is a process that involves the growth, migration and differentiation of endothelial Clofazimine to form new blood vessels. Angiogenesis favorably influences tumor growth and also influences tumor invasion of vessels, resulting in tumor meta

• br Introduction Heart failure HF is

  2024-04-10

  

  Introduction Heart failure (HF) is a chronically progressive disease and one of the most important causes of morbidity and mortality worldwide despite recent improvements in its treatment [1], [2], [3]. The mortality and morbidity benefits of angiotensin converting enzyme inhibitor (ACEI) are wel

• It has been proposed that

  2024-04-10

  

  It has been proposed that angiotensin II (Ang II) may upregulate COX-2 expression and the subsequent vasoconstrictor prostanoids production through the activation of AT-1 receptors in vascular smooth muscle cells (Hu et al., 2002). Additionally, this peptide is also able to stimulate the generation

• br Introduction Chronic kidney disease CKD

  2024-04-09

  

  Introduction Chronic kidney disease (CKD) is a worldwide public health problem. This problem is even worse in socioeconomically deprived countries because lower income and social deprivation are associated with higher incidence of reduced GFR, progressive kidney function loss and end stage renal

15149 records 121/1010 page Previous Next First page 上5页 121122123124125 下5页 Last page