• A breakthrough in the understanding

  2022-08-18

  

  A breakthrough in the understanding of the unique properties of GPX4-downregulation-induced cell death was accomplished when Seiler et al. in 2008 demonstrated the role of 12/15-lipoxygenase (12/15-LOX), a polyunsaturated fatty BMS 777607 metabolizing enzyme [92], in the execution of GPX4-knockout-

• FBP ALDOA complex is located on

  2022-08-18

  

  FBP2-ALDOA complex is located on both sides of Z-line in striated muscles (Rakus et al., 2003a; Gizak et al., 2003) and its stability is regulated by calcium ions (Mamczur et al., 2005; Rakus et al., 2013) (Fig. 3). An increasing titre of [Ca2+] which occurs during muscle contraction stimulates diss

• Genome wide binding and transcriptome

  2022-08-17

  

  Genome-wide binding and transcriptome analyses demonstrate that Fbxl10 directly binds the Areg, Mdk, Lmnb1, Thbs1, Mgp and Cxcl12 locus and thereby might influences the expression of these migration associated genes. The expression of epidermal growth factor (EGF)-like molecule Amphiregulin (Areg)

• In addition to acting as the gatekeeper for the metabolic

  2022-08-17

  

  In addition to acting as the gatekeeper for the metabolic and antioxidant roles of glucose, HKs have also been found to regulate mPTP opening directly. First described in the cancer field, the high-affinity HK isoforms HK1 and HK2 are strongly anti-apoptotic when bound to the outer mitochondrial mem

• Organisms can adapt to increasing ROS production by up

  2022-08-17

  

  Organisms can adapt to increasing ROS production by up-regulating antioxidant defences, such as the activities of antioxidant enzymes (Livingstone, 2003). Failure of antioxidant defences to detoxify excess ROS production can lead to significant oxidative damage including enzyme inactivation, protein

• The GSTP promoter region in

  2022-08-17

  

  The GSTP1 promoter region in PCA cells without or with reduced GSTP1 mRNA expression had a different histone modification pattern than BPH-1 cells with GSTP1 mRNA expression: the repressive histone modifications H3K9me3/H3K27me2 were distinctly increased and H3K27me3/H3K9me2 were slightly decreased

• br GSK The GSK family is highly conserved throughout

  2022-08-17

  

  GSK-3 The GSK-3 family is highly conserved throughout evolution and is encoded by two genes, GSK-3α and GSK-3β, which are located in chromosomes 19q13.2 and 3q13.3 in human, respectively. Both GSK-3α and GSK-3β proteins exist in a variety of tissues with the highest levels found in p53 inhibitor

• br Introduction Verticillium dahliae Kleb is

  2022-08-17

  

  Introduction Verticillium dahliae (Kleb.) is a soil-borne fungal pathogen that is able to infect hundreds of plant species, and causes vascular wilt disease [1], [2]. In nature, the infection of V. dahliae initiates from the germination of resting structures called microsclerotia [3]. The germina

• br Glycoprotein Production br Strategies to Obtain Glycoprot

  2022-08-17

  

  Glycoprotein Production Strategies to Obtain Glycoprotein Compositional Homogeneity Glycoproteins are modified by glycosyltransferases and glycosylhydrolases in the ER and Golgi; however, the degree of remodeling for each glycan on each protein is not explicitly defined by a template (Moremen

• In teleosts GR is expressed in almost every

  2022-08-17

  

  In teleosts, GR is expressed in almost every cell and regulates genes controlling development, metabolism, and immune response [17,18]. Several teleosts contain two GR genes, GR1 and GR2 [8]. Other groups have found only one GR in some species thus far, such as the Japanese flounder, brown trout, an

• As early as glucagon was shown to increase energy

  2022-08-17

  

  As early as 1957, glucagon was shown to increase Bestatin hydrochloride receptor expenditure in rodents in both pair-feeding studies and through directly increasing oxygen consumption [23], [24]. This has more recently been confirmed in man, through indirect calorimetry during glucagon infusions [2

• An advantage of photolabeling with tritiated

  2022-08-16

  

  An advantage of photolabeling with tritiated photoprobes followed by microsequencing with Edman degradation is the ability to both identify the photolabeled BCATc Inhibitor 2 receptor and to quantify photoincorporation which enables assessment of pharmacological specificity and allosteric interacti

• Bisindolylmaleimide VIII acetate australia br Introduction T

  2022-08-16

  

  Introduction The fibroblast growth factor receptor (FGFR) pathway is an important oncogenic driver in malignant cancer. It controls cellular processes such as cell proliferation, differentiation, migration, Bisindolylmaleimide VIII acetate australia progression, metabolism, and survival. In non–

• CPI-203 Through the analysis of various synthetic GPR

  2022-08-16

  

  Through the analysis of various synthetic GPR40 agonists as reported in literature, we found that a number of these compounds contained a phenylpropanoic CPI-203 motif which was inspired from naturally occurring medium to long chain fatty acids. For instance, in the early period of discovering TAK-

• br Declaration of interest br Acknowledgments br

  2022-08-16

  

  Declaration of interest Acknowledgments This work was supported by grants from the Polish National Science Centre (PRELUDIUM grant no. 2013/11/N/NZ5/00270) and the European Commission FP7 Project Beta-JUDO (grant number 279 153), European Union EIT Health project DeTecT2D, Swedish Diabetes A

15901 records 373/1061 page Previous Next First page 上5页 371372373374375 下5页 Last page