• From the same perspective previous studies by

  2020-07-27

  

  From the same perspective, previous studies by Sajdyk and colleagues (Sajdyk et al., 1999) and Spiga and colleagues (Spiga et al., 2006) have shown that the administration of CRF or urocortin 1 (a selective agonist for CRF1 and CRF2 receptors but with a higher affinity for the CRF1 receptor) into th

• The finding that C forms

  2020-07-27

  

  The finding that C75 forms a CoA adduct before it can inhibit CPT1 is reminiscent of the case of etomoxir. McGarry and co-workers [43], [44] showed that the CPT1 inhibitory molecules were neither tetradecylglycidic Fmoc-Gln(Trt)-OH australia nor etomoxir themselves, but rather their CoA esters prod

• br Introduction Currently the great

  2020-07-27

  

  Introduction Currently, the great offer of unhealthy diets, rich in saturated fat, increases the prevalence of metabolic disorders [1], [2], [3]. The metabolic syndrome is already established in the worldwide population and is not limited to overweight or obese persons. This disorder refers to a

• A leading approach to improving

  2020-07-27

  

  A leading approach to improving the half-life of a protein therapeutic is to reduce its renal clearance rate, e.g. by increasing its size above the renal cut-off of 40–50 kDa. Several ways can achieve this, including chemical and post-translational modification as well as by genetic engineering [7].

• The radioactivity levels in baboon plasma

  2020-07-27

  

  The radioactivity levels in baboon plasma peaked around one min post injection, followed by a gradual clearance (, n = 4). High-performance liquid chromatography (HPLC) analyses of the plasma samples indicated no significant metabolism of [C]TMI in the baseline scans (, n = 3). However, a relatively

• In the proposed language a concrete architectural model cons

  2020-07-27

  

  In the proposed language, a concrete architectural model consists of a set of individual components (ConcreteComponent) and a set of relationships (Relationship) among them. Each component has a type, defined by ComponentType. The container component type identifies a component that contains other c

• br Oxysterols as Key Players in Metabolic Syndrome

  2020-07-26

  

  Oxysterols as Key Players in Metabolic Syndrome? Obesity and sedentary lifestyle are on the rise and pose serious threats to people\'s health and wellbeing. Obesity is often associated with other pathologies and is one of the criteria included in the definition of metabolic syndrome (MetS) (see G

• Having generated synthetic cytokines and synthetic cytokine

  2020-07-25

  

  Having generated synthetic cytokines and synthetic cytokine receptors, the logical next step has been to design fully synthetic cytokine/cytokine receptor systems, modifying either cytokine/cytokine receptor binding interfaces or cytokine-unrelated combinations of substances and their binding domain

• Among the various neurotransmitter systems pointed out

  2020-07-25

  

  Among the various neurotransmitter systems pointed out to play a role in the mediation of defensive and antinociceptive responses elicited by environmentally aversive stimuli, the neuropeptide corticotropin-releasing factor or hormone (CRF or CRH) has attracted the interest of many researchers inves

• Haggar et al reported the synthesis

  2020-07-25

  

  Haggar et al. reported the synthesis of two new series of 8-(2-imino/oxo/thioxo pyrimidin-4-yl)-4-methyl-6-nitro-2-oxo-2H-chromen-7-yl benzoates 56 (X=O, S, NH) and 8-(pyrazol-3-yl)-4-methyl-6-nitro-2-oxo-2H-chromen-7-yl benzoates 57 [Y=C(O)CH3, 2,4-(NO2)2C6H3]. The 8-acetyl-4-methyl-6-nitro-2-oxo-2

• Emi protein consists of an N terminal regulatory region and

  2020-07-25

  

  Emi2 protein consists of an N-terminal regulatory region and a C-terminal functional region. The C-terminal region contains a destruction box (D-box), which likely competes with APC/C substrates (including cyclin B) for APC/C binding, and a zinc-binding region (ZBR), which somehow inhibits APC/C ubi

• br Results and discussion br Conclusions In conclusion we ha

  2020-07-25

  

  Results and discussion Conclusions In conclusion, we have developed rational strategies that allowed us to successfully identify a series of novel analogs structurally related to to modulate the activity of estrogen-related receptors (ERRγ and ERRβ), which are constitutively active. All of th

• Omar Farha and coworkers have

  2020-07-25

  

  Omar Farha and coworkers have recently successfully employed metal-organic frameworks (MOFs) to tackle these limitations while retaining the essential characteristics of an immobilization material. MOFs consist of metal ions, or small clusters thereof, coordinated with organic ligands. MOFs are high

• The contribution of local ETA and ETB receptors towards heat

  2020-07-25

  

  The contribution of local ETA and ETB receptors towards heat hyperalgesia induced by inoculation of XC tumor RG2833 mg in the paw of mice has been demonstrated by Baamonde and colleagues (Baamonde et al., 2004). Furthermore, using neuropathic and inflammatory nociception models, several studies have

• Recently cross talk between DDR and the insulin

  2020-07-25

  

  Recently, cross-talk between DDR2 and the insulin receptor and between Notch1 and DDR1 was proposed. Stimulation of cells with collagen I and insulin promotes Tyr740 as well as total tyrosine phosphorylation of DDR2 receptor to a greater extent than the phosphorylation stimulated by collagen I alone

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