• reductase enzyme Regarding our controls there is empirical

  2018-10-30

  

  Regarding our controls, there is empirical support for our findings associated with the marriage growth rate in several micro studies (Gunnell, Middleton, Whitley, Dorling, & Frankel, 2003; Kposowa, 2000). These scholars claim that suicide rates are lower for married than for unmarried persons, and

• br Comentarios finales Ucrania ha vivido peores adversidades

  2018-10-30

  

  Comentarios finales Ucrania ha vivido peores adversidades que países como México o Estados Unidos y no ha tenido la atención que debería; en estas naciones las contracciones en el producto durante las crisis más severas no se comparan con lo que ha experimentado Ucrania. Cuando México sufrió la c

• Extensive data in the literature support a possible protecti

  2018-10-30

  

  Extensive data in the literature support a possible protective role for Abs directed against the crown of the V3 loop. The proof of principle that human monoclonal Abs (mAbs) specific for the V3 loop could react with and neutralize many strains of HIV, including lab-adapted and primary isolates from

• The knowledge about Taspase and its particular activation me

  2018-10-30

  

  The knowledge about Taspase1 and its particular activation mechanism was subsequently used to design a dominant-negative variant of Taspase1 (dnTASP1). This mutant combines the S291A and C163E mutations. Therefore, such a mutant monomer — per se unable to become activated itself — binds with the mod

• L pneumophila is a Gram negative facultative intracellular b

  2018-10-30

  

  L. pneumophila is a Gram-negative facultative intracellular bacterium that multiplies in aquatic environments, especially in free-living protozoa and biofilms (Newton et al., 2010; Carratalà and Garcia-Vidal, 2010). Legionellosis is an acute pneumonia caused by inhalation of aerosols containing Legi

• Once in advanced stage of immune deficiency patients infecte

  2018-10-30

  

  Once in advanced stage of immune deficiency, patients infected with HIV have an increased risk of cancer development. For example primary effusion lymphoma (PEL) is a high-grade non-Hodgkin\'s lymphoma of B-cell origin that is predominantly found in HIV-seropositive individuals (Horenstein et al., 1

• br Author contributions br Declaration of interests

  2018-10-30

  

  Author contributions Declaration of interests Acknowledgements This publication made use of the Neisseria Multi Locus Sequence Typing website (http://pubmlst.org/neisseria/) developed by Keith Jolley and sited at the University of Oxford (Jolley and Maiden, 2010). The development of this

• Controlling the immune dysfunctions and overcoming the short

  2018-10-30

  

  Controlling the immune dysfunctions and overcoming the shortage of islet β jnk inhibitors are two critical steps for the treatment of T1D. Conventional immunotherapies (e.g., CD3 and CD20 mAb treatments) targeting the general immune cell compartment usually leads to the absolute decline of cell num

• Restriction of conditionally essential amino acids in the di

  2018-10-30

  

  Restriction of conditionally essential amino acids in the diet could also impact health. Arginine serves as a precursor for the synthesis of nitric oxide, creatine, symmetric and asymmetric dimethylarginine, and polyamines, and is interconvertible with proline and glutamate (Wu, 2009). Glutamine is

• br Author contributions br Conflicts of Interest

  2018-10-30

  

  Author contributions Conflicts of Interest Introduction With 15 million units transfused per year, red blood cell (RBC) transfusion is the most common procedure performed in United States hospitals (Pfuntner et al., 2013). Exposure to numerous foreign non-ABO RBC antigens during transfusion

• A potential limitation of our study was the use

  2018-10-30

  

  A potential limitation of our study was the use of hospital controls as proxies of healthy people. Controls were admitted for a wide variety of routine conditions unrelated to tobacco and it is implausible that a high proportion of the controls with a detectable damaging TP53 mutation developed a ca

• Despite a clear oncogenic role

  2018-10-29

  

  Despite a clear oncogenic role for NFIB in SCLC and melanoma, tumour suppressive functions have been demonstrated or strongly suggested in other cancers. Although the molecular mechanisms behind its anti-oncogenic functions are not well understood, the fact that NFIB is widely expressed in multiple

• br Experimental design materials and

  2018-10-29

  

  Experimental design, materials and methods Conflict of interest Acknowledgment We wish to thank the Academy of Finland (Center of Excellence in Biomembrane Research, project no. 2721130), and the European Research Council (Advanced Grant project CROWDED-PRO-LIPIDS) for financial support. Fo

• br Experimental design materials and methods br Acknowledgme

  2018-10-29

  

  Experimental design, materials and methods Acknowledgments We are grateful for funding from ESRC under Grant reference no ES/K004824/1. We are also grateful for the services of the Secure Data Service support team. Specifications Table Value of the data Data The dataset consists of cross

• As a model of prenatal adversity we chose maternal cigarette

  2018-10-29

  

  As a model of prenatal adversity, we chose maternal cigarette smoking during pregnancy (MSP). This choice reflects high prevalence of MSP in the general population; the latest results of the National Survey on Drug Use and Health (U.S.A.) suggest that smoking during pregnancy has not changed signifi

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