• Progress made regarding the molecular characterization of

  2018-11-07

  

  Progress made regarding the molecular characterization of the disease-causing Spadin has now opened the door for new forms of allergen-specific immunotherapy which allow reduced side effects and targeting of specific pathways of the allergic immune response (Niederberger et al., 2004, Creticos et al

• This latter study is particularly important in the context o

  2018-11-07

  

  This latter study is particularly important in the context of vaccine refusal, since it supports a growing body of research which underscores the role of clusters of non-vaccinators in lowering herd immunity and allowing for disease outbreaks (Salathé and Bonhoeffer, 2008; Liu et al., 2015). The US

• HLA transgenic mice are widely used to model the human

  2018-11-07

  

  HLA-transgenic mice are widely used to model the human T cell response in mice. We focused the present study on the HLA B*0702 allele, which is associated with strong T cell response in terms of magnitude and breath (Weiskopf et al., 2013), thereby allowing us to test the role of multiple cross-reac

• tiger Here we sought to characterize

  2018-11-07

  

  Here we sought to characterize the contribution of DGKα and DGKζ to the generation of non-conventional bystander memory-like CD8+ T cell populations. We show that DGKζ deficiency, but not that of DGKα leads to increased output of CD44hiCD122hi CD8+ T tiger and facilitates IL-2 and IL-15 responses.

• Here we sought to characterize

  2018-11-07

  

  Here we sought to characterize the contribution of DGKα and DGKζ to the generation of non-conventional bystander memory-like CD8+ T cell populations. We show that DGKζ deficiency, but not that of DGKα leads to increased output of CD44hiCD122hi CD8+ T induced pluripotent stem cell and facilitates IL

• special health care needs In spite of these interesting obse

  2018-11-07

  

  In spite of these interesting observations, some additional questions arise from the study. For example, consistent with previous reports, circadian phase and period length are influenced by diet (). However, here the HFD has the general effect in WT mice of shortening period length rather than leng

• br Funding This research was supported by a grant from

  2018-11-07

  

  Funding This research was supported by a grant from the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health & Welfare, Republic of Korea (grant number: HI14C1731) and funded by the Ministry of Education, Science and

• Mechanistically the age promoting effects

  2018-11-07

  

  Mechanistically, the age-promoting effects of senescence are associated with the restriction of regenerative capacity of stem and progenitor thrombin inhibitors (Choudhury et al., 2007; Jurk et al., 2014) as well as the secretion of bioactive molecules (the so-called SASP (Coppe et al., 2008)), spe

• Intramuscular IM oxytocin international units IU was identif

  2018-11-07

  

  Intramuscular (IM) Aminoallyl-dCTP - Cy3 (10 international units [IU]) was identified as one of 13 life-saving commodities for women and children in a 2012 United Nations (UN) Commission Report (United Nations, 2012), and was included in the World Health Organization (WHO) model list of essential me

• br Data experimental design materials and methods

  2018-11-07

  

  Data, experimental design, materials and methods Specifications table Value of the data Data Mean peak values obtained from intact glucose assay (IC), detergent-soluble extracts (SD) and detergent-insoluble extracts (ID) associated with immature (IC2, SD2, ID2) and mature epididymal sper

• Specifications table br Value of

  2018-11-07

  

  Specifications table Value of data 1. Experimental design, materials and methods 2. Direct link to deposited data Deposited data can be found here: http://www.ncbi.nlm.nih.gov.eleen.top/GBRH01000000. 3. Nucleotide sequence accession number The assembled and annotated A. donax USA p-gp

• br Specifications table br Value

  2018-11-07

  

  Specifications table Value of the data Data Experimental design, materials and methods Fractionation of human plasma samples Frozen human plasma samples from healthy volunteers were obtained from expired stocks of local blood banks, pooled and fractionated by anion exchange chromatogr

• Data experimental design materials and methods

  2018-11-07

  

  Data, experimental design, materials and methods Conflict of interest Acknowledgements We would like to acknowledge the BBSRC for support (grant BB/H001948/1), the Chemical Analysis Facility at the University of Reading for access to the Orbitrap instrument, the Centre for Advanced Microscopy

• Considering developmental aspects children may have had more

  2018-11-07

  

  Considering developmental aspects, children may have had more difficulties to implement reappraisal as adults, constricting their ability to stay on task during the whole block. Moreover, during childhood, cognitive control-related PFC activity is known to undergo substantial developmental changes (

• The current results are consistent with the animal

  2018-11-07

  

  The current results are consistent with the animal models of cannabinoid exposure during adolescence (Rubino et al., 2008; Schramm-Sapyta et al., 2007) and suggest that more human research is needed on the long-term effects of cannabis use in adolescence. In consideration of the animal studies and t

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