• While the first case of IA was

  2018-11-09

  

  While the first case of IA was described in 2000 from Norway (Ringertz et al., 2000), it is remarkable that no additional cases of IA were documented over the following 10years. The largest subsequent cluster of IA cases occurred in 2009–10 and predominantly centered in Scotland (Team, 2011). Other

• The opposing effects of FGF and FGF on bile acid

  2018-11-09

  

  The opposing effects of FGF21 and FGF15/19 on bile HMBA Linker synthesis observed in our studies raises the question of whether FGF21 is an endogenous regulator of FGF15/19. It is interesting to note that, diabetic animals and humans have elevated bile acid pool and fecal bile acids with impaired F

• br Introduction Skeletal muscle development is

  2018-11-08

  

  Introduction Skeletal muscle development is carried out by a reservoir of progenitor cells, which differentiate and fuse into multinucleated syncytia during several distinct but overlapping stages: early embryonic, mid-late embryonic, fetal, perinatal and adult (for review see Tajbakhsh, 2009). F

• Introduction Stroke remains a leading cause of adult disabil

  2018-11-08

  

  Introduction Stroke remains a leading cause of adult disability worldwide. In Brazil it is the leading cause of death, with a mortality rate of approximately 51.6 deaths per 100,000 inhabitants (Garcia et al., 2009) and shows the highest case-fatality rate in Latin America (Lotufo and Bensenor, 200

• Direct genetic reprogramming of postnatal primary cells by

  2018-11-08

  

  Direct genetic reprogramming of postnatal primary cells by forced expression of key developmental transcription factors has emerged as an alternative to in vitro differentiation of PSCs. This strategy has been used successfully to produce functional cells, including neurons, hepatocyte-like cells an

• The model of this current study showed that

  2018-11-08

  

  The model of this current study showed that CD133 and CD24 markers, as a single or combined expression, are so promiscuous that they are not able to identify a pure population of adult renal stem cells. In PKHhigh cells, the only cell population presenting self-renew and an in vitro multipotency cap

• To develop an effective cell

  2018-11-08

  

  To develop an effective cell-based therapy against neurodegenerative disorders of the CNS, efficient recruitment of the cells into the CNS is essential. Previous findings suggest that particular bone marrow derived cells are able to cross the blood–brain barrier (Lebson et al., 2010; Simard and Rive

• br Acknowledgments We thank all the

  2018-11-08

  

  Acknowledgments We thank all the members of Wagers laboratory and E. Gussoni and E. Dzierzak for helpful discussions. We also thank A. Wakabayashi, G. Buruzula and J. LaVecchio at Joslin/HSCI Flow Cytometry Core for excellent flow cytometry support, funded in part by NIHP30 DK036836. This work wa

• br Materials and methods br Results br Discussion This

  2018-11-08

  

  Materials and methods Results Discussion This present study and previous works in the literature have shown that mechanical stimulation promotes the proliferation of BMSCs (Luu et al., 2009). In this study, the presented results revealed that pressure promoted BMSC proliferation by facilita

• Our coculture experiments demonstrated that all three MSCs s

  2018-11-08

  

  Our coculture experiments demonstrated that all three MSCs showed a similar low in vitro proliferation; for most patients coculture of all three MSCs with primary human AML trp channels did not alter MSC proliferation but a minor increase in the proliferation was seen for a minority of patients. No

• ginsenoside rh2 This study was approved by

  2018-11-08

  

  This study was approved by the Institutional Stem Cell Research Oversight (ISCRO) committee in the Johns Hopkins University. Blood CD34+ ginsenoside rh2 were obtained with an informed consent from the patient. Materials and methods Acknowledgments We thank the patient for providing blood sam

• The WNT signaling pathway is a

  2018-11-08

  

  The WNT signaling pathway is a primary determinant in assigning an A/P positional identity to NPCs. This instructional cue is imparted early during NPC generation and once this identity is established, it is stable and cannot be altered through exogenous manipulation of the WNT pathway. Using a WNT

• The pleiotropic nature of FGF

  2018-11-08

  

  The pleiotropic nature of FGF2 and its variety of downstream effects make generation of highly pure active protein essential. Heparin chromatography has been used for purification of 18kDa FGF2 isoform. However, subsequent heparin contamination in purified FGF2 preparations has been previously descr

• br Materials and methods br Results

  2018-11-08

  

  Materials and methods Results Discussion NPY is one of the most common neuropeptides in mammals, and it is abundant in the central and peripheral nervous system. Recent studies have indicated that the neuropeptides SP and NPY can regulate many biological activities in BMSCs and MC3T3 src ki

• Neuroanatomical studies indicate that DARPP neurons

  2018-11-08

  

  Neuroanatomical studies indicate that DARPP32+ neurons could be divided into two populations: one that constructs a direct pathway and another that constructs an indirect pathway. DARPP32+ neurons in the direct pathway express DRD1 and are located in the striosome. On the other hand, those in the in

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