• br Experimental Procedures br Acknowledgments br Introductio

  2018-10-24

  

  Experimental Procedures Acknowledgments Introduction Hepatitis C virus (HCV) infects an estimated 2%–3% of the world population and is a major cause of liver disease and cancer. It is estimated that more than 350,000 people die of the HCV-related liver disease each year (Te and Jensen, 2010

• br Results br Discussion This work represents a number

  2018-10-24

  

  Results Discussion This work represents a number of important advances for the study of axolotl regeneration. First, we have shown for several genomic loci that TALENs and CRISPRs can induce targeted deletions in a large proportion of cells from injected animals. In all cases, CRISPRs yielded

• sirtuin 1 Although the disease specific phenotype

  2018-10-24

  

  Although the disease specific phenotype identified in this study will be invaluable for demonstrating the efficacy of gene based therapeutics, two major questions remain: 1) why do some patients with TRNT1 variants develop the severe syndromic disease SIFD while others (i.e. the three presented in t

• Multi electrode array approaches have been proposed as

  2018-10-24

  

  Multi-electrode array approaches have been proposed as a tool for detecting functional changes in electrically excitable cells, including neurons, exposed to drugs or toxins and allow use in high throughput studies (McConnell et al., 2012). Although there are a number of electrophysiological measure

• To address this issue we examined

  2018-10-24

  

  To address this issue, we examined striatal neurons innervated by nigral DA neurons using the plant lectin wheat-germ agglutinin (WGA). WGA can be efficiently transferred between neurons via synapses and has been already used as a transsynaptic tracer (Fabian and Coulter, 1985; Broadwell and Balin,

• Traditionally testing of hPSC lines for gross chromosomal ch

  2018-10-24

  

  Traditionally, testing of hPSC lines for gross chromosomal changes employed karyology by chromosome banding of metaphase cftr inhibitor (Amps et al., 2011; Baker et al., 2007). Although karyotyping allows examination of the entire cell genome in a single assay, an often overlooked issue in evaluatin

• phosphatidylinositol 4-kinase br Introduction Human induced

  2018-10-24

  

  Introduction Human induced pluripotent stem phosphatidylinositol 4-kinase (hiPSCs) carry the whole genetic context of a patient and can be a virtually unlimited source of differentiated cell types of interest. Increasingly, hiPSCs are being applied for disease modeling and drug screening for a n

• If we consider the absorption of solar

  2018-10-24

  

  If we consider the cytoskeleton of solar radiation without the ‘greenhouse glass’ in the range of emission frequencies of the Earth\'s surface, as well as in the frequency band of solar radiation adjacent to it, up to 3000cm (prior to our examination of the problem, it was a boundary above which th

• being a square root of the volume V

  2018-10-24

  

  being a square root of the volume V/2π2, will be considered as arbitrary real . Now, according to our choice of the cosmic time (6) which is canonically conjugate to the kinetic energy of the scalar field (5), the WDW equation in the slow-roll regime can be replaced by the time-dependent Schrödinge

• br Distinguishing features of and

  2018-10-24

  

  Distinguishing features of, and selected tensions within, a model-based perspective A model-based perspective emphasizes the processes producing outcome variation, and observed data are used to characterize that data-generating process. This is the majority perspective in statistical textbooks, i

• The use of good quality instruments is necessary when

  2018-10-24

  

  The use of good quality instruments is necessary when examining associations between adolescents’ neighbourhood social environments and their health and well-being. Different approaches are taken to conceptualisation, operationalisation and measurement which might explain inconsistent research findi

• The present study directly compares attitudes about female

  2018-10-24

  

  The present study directly compares attitudes about female genital cutting among Sudanese living in Switzerland to attitudes among Sudanese living in Sudan. Whether or not Sudanese immigrants are a special subset of the Sudanese population, and regardless of whether or not they move toward the value

• Wicksell p found it remarkable that from a technical point

  2018-10-23

  

  Wicksell (1958 [1900]), p. 105) found it “remarkable” that “from a technical point of view” production attains its maximum under free competition. He claimed throughout volume 1 of his Lectures (pp. 164–165, 196–197) the significance of his demonstration that the search for maximum net profit leads

• br Introduction Although the incidence of

  2018-10-23

  

  Introduction Although the incidence of HIV has peaked in much of sub-Saharan Africa, the tuberculosis (TB) epidemic continues unabated with TB remaining the leading cause of death in those living with HIV (World Health Organization, 2014). While many studies have investigated the impact of HIV in

• br NGS Panel for Diagnosis of

  2018-10-23

  

  NGS Panel for Diagnosis of Early and Severe Forms of Polycystic Kidney Disease Polycystic kidney disease (PKD) is one of the most common potentially life-threatening human genetic disorders, and early and severe PKD occur in patients with the autosomal recessive form (ARPKD) and 2–5% of the autos

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