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br Material and methods br Acknowledgment The authors would
2018-10-22
Material and methods Acknowledgment The authors would like to thank Mr. Chee Peng Ng (Institute of Molecular and Cell Biology, Singapore) for his help on the electron scanning microscope and Dr. William Birch (Institute of Materials Research and Engineering, Singapore) for his critical review
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It has not been reported
2018-10-22
It has not been reported whether behaviors of EPCs can be regulated by applied EFs. To be able to manipulate cellular behaviors of EPCs, and to direct EPCs to sites where angiogenesis is required, may have significant clinical implication in tissue engineering, and in controlling angiogenesis and ma
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Multiple enrichment schemes have been
2018-10-22
Multiple enrichment schemes have been devised to separate CMs from non-CMs by exploiting cell-specific physical and biological characteristics (Huber et al., 2007; Xu, 2012). Highly purified embryonic stem cell (ESC)-derived CMs populations have been isolated from ESC lines transduced with CM-specif
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The functional roles of SOX in human pluripotency maintenanc
2018-10-22
The functional roles of SOX2 in human pluripotency maintenance and lineage differentiation were recently reported (Wang et al., 2012). SOX2 is not essential for hESC self-renewal. However, overexpression of SOX2 results in the promotion of neural ectodermal differentiation and the suppression of def
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Several cytokines and chemokines possess important chemo att
2018-10-20
Several cytokines and chemokines possess important chemo-attractant functions during fetal CNS development (Stumm and Hollt, 2007; Li and Ransohoff, 2008). This suggests that neural stem and precursor buy LY2109761 may respond to cues by these mediators of inflammation in immune-mediated pathologic
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Previously we demonstrated that injured kidney tissues can
2018-10-20
Previously, we demonstrated that injured kidney tissues can induce bone marrow stromal p-Cresyl sulfate to differentiate into renal tubular epithelial-like cells in vitro and in vivo (Qian et al., 2008). However, another work reported that the beneficial effects of BMSCs are primarily mediated by c
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Finally the potential contribution of CD b cells to
2018-10-20
Finally, the potential contribution of CD11b+ salt inducible kinase to the regenerative microenvironment highlights the experimental challenges in defining the mechanism of lung growth. The distinct transcriptional profiles of the CD11b+ cells, and their migration into different anatomic compartmen
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Intestinal stem cells have been identified by various marker
2018-10-20
Intestinal stem cells have been identified by various markers, such as musashi-1 (Msi1), hairy enhancer of split-1 (Hes1), CD133, leucine-rich repeats and immunoglobulin-like domains protein 1 (Lrig1) (Kayahara et al., 2003; Potten et al., 2003; O\'Brien et al., 2007; Wong et al., 2012). More recent
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The following are the supplementary data related
2018-10-20
The following are the supplementary data related to this article. Acknowledgments Introduction Inflammation, trauma and tumors may all lead to articular cartilage defects. However, the treatment of these defects remains a clinical challenge. Currently, clinical treatments for articular cartil
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ppar gamma agonist A recent study showed that mesenchymal AL
2018-10-20
A recent study showed that mesenchymal ALK5 regulates the balance between smooth muscle versus lipofibroblast differentiation and that ALK5 inhibition shifts the balance towards lipofibroblast (Li et al., 2014). Thus, it is possible that the enhancing effect of ALK5-I we observed in our culture syst
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br Resource details Human skin fibroblasts
2018-10-20
Resource details Human skin fibroblasts isolated from a 26year old Puerto Rican female HPS1 patient were obtained from the Coriell Cell Repositories (Camden, NJ). The parental line, GM14609, carries a homozygous 16bp duplication (codons 491–496) in exon 15 of the HPS1 gene. The latrunculin were
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The following is the supplementary data related to
2018-10-20
The following is the supplementary data related to this article. Authors\' contributions O.F. contributed to prepare experimental design, performed Ca measurements, helped with data and statistical analysis, immunocytochemistry, confocal imaging, and contributed in manuscript writing. Disclos
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br The ethics of cell therapy Clearly then cell
2018-10-20
The ethics of cell therapy Clearly then, cell therapy and regenerative medicine in general raise a number of ethical, economical and regulatory issues that were addressed in an ad hoc session. As a general introduction to this very complex landscape, John Harris (University of Manchester) took le
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The negative long term effects of
2018-10-20
The negative, long term effects of alcoholism on bone mass have been well-established (Feskanich et al., 1999). Studies have shown that heavy chronic alcohol consumption compromises bone quality and increases the risk for osteoporosis. Other studies have shown that alcoholism is associated with a va
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Induction of EndMT results from integration of
2018-10-20
Induction of EndMT results from integration of multiple extrinsic inputs within the dynamically shifting cellular environment of cardiogenesis. Owing to the membrane bound presentation of ligands, Notch signaling status is dependent on the organization and distribution of signal-presenting and signa
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