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Main Text Just years since
2018-10-31
Main Text Just 10 years since the development of human induced pluripotent stem cell (hiPSC) technology (Takahashi et al., 2007), the use of these cells to model order BX-795 disorders and obtain disease-relevant information is becoming a tangible reality. Not only are we now able to better detect
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The pituitary gland is considered
2018-10-31
The pituitary gland is considered the master gland of hormone function. Hypopituitarism is a disease condition with insufficient or absent function of the pituitary gland. Pituitary tumors are the most common cause but many other triggers can induce pituitary dysfunction including inborn genetic def
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The full spin of the
2018-10-30
The full spin of the Fe2+ ion can be equal to 4/2 or depending on whether external molecular complex is adjoined to it. Let us note that this property determines the possibility of the oxygen transport by the red blood polo like kinase in living organisms. It is shown in this paper that, in the ca
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reductase enzyme Regarding our controls there is empirical
2018-10-30
Regarding our controls, there is empirical support for our findings associated with the marriage growth rate in several micro studies (Gunnell, Middleton, Whitley, Dorling, & Frankel, 2003; Kposowa, 2000). These scholars claim that suicide rates are lower for married than for unmarried persons, and
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br Comentarios finales Ucrania ha vivido peores adversidades
2018-10-30
Comentarios finales Ucrania ha vivido peores adversidades que países como México o Estados Unidos y no ha tenido la atención que debería; en estas naciones las contracciones en el producto durante las crisis más severas no se comparan con lo que ha experimentado Ucrania. Cuando México sufrió la c
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Extensive data in the literature support a possible protecti
2018-10-30
Extensive data in the literature support a possible protective role for Abs directed against the crown of the V3 loop. The proof of principle that human monoclonal Abs (mAbs) specific for the V3 loop could react with and neutralize many strains of HIV, including lab-adapted and primary isolates from
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The knowledge about Taspase and its particular activation me
2018-10-30
The knowledge about Taspase1 and its particular activation mechanism was subsequently used to design a dominant-negative variant of Taspase1 (dnTASP1). This mutant combines the S291A and C163E mutations. Therefore, such a mutant monomer — per se unable to become activated itself — binds with the mod
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L pneumophila is a Gram negative facultative intracellular b
2018-10-30
L. pneumophila is a Gram-negative facultative intracellular bacterium that multiplies in aquatic environments, especially in free-living protozoa and biofilms (Newton et al., 2010; Carratalà and Garcia-Vidal, 2010). Legionellosis is an acute pneumonia caused by inhalation of aerosols containing Legi
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Once in advanced stage of immune deficiency patients infecte
2018-10-30
Once in advanced stage of immune deficiency, patients infected with HIV have an increased risk of cancer development. For example primary effusion lymphoma (PEL) is a high-grade non-Hodgkin\'s lymphoma of B-cell origin that is predominantly found in HIV-seropositive individuals (Horenstein et al., 1
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br Author contributions br Declaration of interests
2018-10-30
Author contributions Declaration of interests Acknowledgements This publication made use of the Neisseria Multi Locus Sequence Typing website (http://pubmlst.org/neisseria/) developed by Keith Jolley and sited at the University of Oxford (Jolley and Maiden, 2010). The development of this
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Controlling the immune dysfunctions and overcoming the short
2018-10-30
Controlling the immune dysfunctions and overcoming the shortage of islet β jnk inhibitors are two critical steps for the treatment of T1D. Conventional immunotherapies (e.g., CD3 and CD20 mAb treatments) targeting the general immune cell compartment usually leads to the absolute decline of cell num
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Restriction of conditionally essential amino acids in the di
2018-10-30
Restriction of conditionally essential amino acids in the diet could also impact health. Arginine serves as a precursor for the synthesis of nitric oxide, creatine, symmetric and asymmetric dimethylarginine, and polyamines, and is interconvertible with proline and glutamate (Wu, 2009). Glutamine is
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br Author contributions br Conflicts of Interest
2018-10-30
Author contributions Conflicts of Interest Introduction With 15 million units transfused per year, red blood cell (RBC) transfusion is the most common procedure performed in United States hospitals (Pfuntner et al., 2013). Exposure to numerous foreign non-ABO RBC antigens during transfusion
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A potential limitation of our study was the use
2018-10-30
A potential limitation of our study was the use of hospital controls as proxies of healthy people. Controls were admitted for a wide variety of routine conditions unrelated to tobacco and it is implausible that a high proportion of the controls with a detectable damaging TP53 mutation developed a ca
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Despite a clear oncogenic role
2018-10-29
Despite a clear oncogenic role for NFIB in SCLC and melanoma, tumour suppressive functions have been demonstrated or strongly suggested in other cancers. Although the molecular mechanisms behind its anti-oncogenic functions are not well understood, the fact that NFIB is widely expressed in multiple
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