• br Results and Discussion br Materials and

  2021-04-30

  

  Results and Discussion Materials and Methods Acknowledgements Introduction Inorganic pyrophosphate is generated as a by-product in several enzymatic reactions in cells. These reactions include DNA and RNA synthesis, activation of fatty acids and amino acids, as well as synthesis of the c

• br Results br Discussion GPCRs recognize

  2021-04-30

  

  Results Discussion GPCRs recognize a broad range of molecules with a vast chemical AG-221 through different mechanisms. Our understanding of the recognition of lipid mediators by GPCRs primarily comes from the structural studies of receptors for lysophospholipids and endocannabinoids includin

• In mouse lung arsenite enhances the formation of

  2021-04-29

  

  In mouse lung, arsenite enhances the formation of cigarette smoke-induced 8-oxodeoxyguanine (Hays et al., 2006) and BaP-induced DNA adducts (Evans et al., 2004). Moreover, arsenite inhibits the repair of BaP-induced DNA adducts in human lung carcinoma A549 Pyronaridine Tetraphosphate (Schwerdtle et

• br Criteria for ER targeted fluorescent probes br Survey of

  2021-04-29

  

  Criteria for ER-targeted fluorescent probes Survey of fluorescent probes Proposed approach to high affinity fluorescent steroidal ER probes Our proposed approach to the development of a new generation of fluorescent estrogen receptor imaging agents employs many of the elements present in th

• It is well known that acrolein a

  2021-04-29

  

  It is well known that acrolein, a metabolite of cyclophosphamide, is responsible for the cyclophosphamide-induced cystitis, and that acrolein is capable of activating TRPA1 channels expressed in the capsaicin-sensitive primary afferents [2], [11]. In this context, it is likely that the early phase o

• Several effective strategies have been developed

  2021-04-29

  

  Several effective strategies have been developed to design activatable MR probes according to the Solomon, Bloembergen and Morgan (SBM) theory, including modulation of the number of inner-sphere water molecules (q), the rotational tumbling time (τ) and the residence lifetime of inner-sphere water mo

• Diagnosis of NCC can be accomplished via imaging techniques

  2021-04-29

  

  Diagnosis of NCC can be accomplished via imaging techniques and serological confirmatory testing. The best immunodiagnostic test for NCC, the enzyme-linked immunotransfer blot EITB (Tsang et al., 1989), is based on the detection of hpdp to one or more of the 7 lentil-lectin glycoproteins (LLGP) of

• Several studies on the collagen receptor DDR have revealed a

  2021-04-29

  

  Several studies on the collagen receptor DDR1 have revealed a defined collagen signaling pathway that causes cell scattering and cadherin switching. As mentioned earlier, DDR gabab receptor on collagens are distinct from integrin binding sites; therefore, the same collagen protein can bind to DDR an

• Due to the high attractiveness of E and E

  2021-04-29

  

  Due to the high attractiveness of E2 and E3 ligases as drug targets, a number of drug discovery assays have been published, based on detection by fluorescence (Dudgeon et al., 2010, Krist et al., 2016, Zhang et al., 2004), AM251 (Davydov et al., 2004, Huang et al., 2005, Kenten et al., 2005, Marbles

• br Conclusion In conclusion DNA methylation is

  2021-04-29

  

  Conclusion In conclusion, DNA methylation is a major epigenetic mark, which regulates temporal and spatial expression of the testicular genes required for normal spermatogenesis process. There are two types of methylation, maintenance and de novo methylation, which are catalysed by DNMT1, DNMT3A

• br Introduction Biocatalysis can be

  2021-04-29

  

  Introduction Biocatalysis can be used to synthesize chiral building blocks, such as monomers for polymer materials, and precursors for pharmaceuticals [[1], [2], [3], [4]]. Enzymes are very suitable for catalyzing reactions with high enantioselectivity to obtain chiral products. For instance, alc

• This research was funded by grants from the National Institu

  2021-04-29

  

  This research was funded by grants from the National Institute on Aging (2R01AG017141-06A2) and the National Center for Complementary and Alternative Medicine (P01AT002034). We also acknowledge the facilities service core of the Environmental Health Science Center (NIEHS ES00240). The authors would

• Several recent reviews have appeared

  2021-04-28

  

  Several recent reviews have appeared covering different aspects of the sPLA2 family of enzymes, including sPLA2-V, and the interested reader is kindly directed to these for specific details [34,[135], [136], [137]]. It is important to remark here, however, that recent studies on sPLA2-V suggest that

• Several studies on the collagen receptor DDR have

  2021-04-28

  

  Several studies on the collagen receptor DDR1 have revealed a defined collagen signaling pathway that causes cell scattering and cadherin switching. As mentioned earlier, DDR clodronate on collagens are distinct from integrin binding sites; therefore, the same collagen protein can bind to DDR and in

• The E enzyme is the apex for downstream

  2021-04-28

  

  The E1 enzyme is the apex for downstream enzymatic cascades and signaling pathways mediated by Ub and Ub-like proteins (Ubls) (Pickart, 2001). Studying characteristics of E1 and its catalytic functions may throw light to the role of ubiquitination in cell development. All known eukaryotic E1 are mon

15850 records 645/1057 page Previous Next First page 上5页 641642643644645 下5页 Last page